SHD — Lactuca sativa

Summary

LsSHD, encoded by gene LSAT_V11C900498010 on lettuce chromosome 9, is a member of the heat shock protein 90 (HSP90) family, containing Hsp90_N, Hsp90_C, and HATPase_C domains. The gene product is associated with ATP-dependent protein folding chaperone activity and has been linked to numerous molecular functions including DNA polymerase activity, transcription regulator activity, and telomeric repeat binding. In lettuce, LsSHD is associated with biological processes such as cellular response to unfolded protein, inhibition of cellular response to heat stress, double-strand break repair, and cellular thermotolerance. The gene has been associated with diverse traits including floral organ morphology, seed set percent, bacterial and viral disease responses, temperature stress response, photoperiod-sensitive flowering time, and aphid response. Localization evidence links the product to the chloroplast outer membrane, ER lumen, and plasma membrane. Studies of related genes in other species connect the family to thermotolerance, disease resistance, and salinity tolerance.