BIN1 — Lactuca sativa

Summary

LsBIN1 (BIN1, also known as CBB2, LsCBB2, LsDWF2, BRI1, LsBRI1, DWF2) on chromosome 2 of garden lettuce encodes a protein with a BRI1 island domain, leucine-rich repeats, and a serine/threonine kinase domain, and is annotated with transmembrane receptor protein tyrosine kinase activity and protein kinase inhibitor activity. The gene is associated with negative regulation of brassinosteroid biosynthesis and activation of brassinosteroid-mediated signaling. It is linked to numerous traits such as stem length, shoot growth angle, leaf growth, root development, seedling hypocotyl length, plant male sterility, and responses to water stress, temperature stress, aluminum, aphids, and wheat powdery mildew. Localization evidence connects the product to the plasma membrane, tonoplast, and endosomal compartments. Studies of related genes in other species link the family to brassinosteroid signaling, immunity, and stress tolerance.