HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C100026420 on lettuce chromosome 1, is a P-type ATPase with a heavy-metal-associated domain. It is annotated with P-type monovalent and divalent copper transporter activity, cadmium exporting ATPase activity, P-type zinc and calcium transporter activity, proton-transporting ATPase activity, transmembrane transporter activity, copper binding, calmodulin binding, ATP hydrolase activity, metal binding, and ATP binding. It is associated with detoxification of copper ion, proton export across plasma membrane, copper ion homeostasis, cell pH regulation, response to toxic substance, cadmium transport, proton transmembrane transport, and membrane transport. The protein localizes to the vacuolar membrane, Golgi membrane, and plasmalemma. LsHMA1 is associated with root length and plant height. Related genes in other species include HMA2, HMA3, HMA4, HMA5, HMA9, LHA1, ACA1, ACA7, ACA10, and ACA3, and are linked to EC numbers 7.2.2.12, 7.2.2.21, 7.2.2.8, 7.1.2.1, 7.2.2.-, and 7.2.2.10.