PAP5 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.7HG0673530 (HvPAP5, also known as HvSAG12) on barley chromosome 7H encodes a papain-like cysteine peptidase of the C1A family, possessing thiol endopeptidase and cysteine-type peptidase activity. It is associated with leaf senescence, programmed cell death, and proteolysis, and has been linked to responses to abscisic acid, ethylene, and gibberellin. The gene product localises to the senescence-associated vacuole, protein storage vacuole, lysosome, and ER lumen, and is associated with the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways, as well as regeneration and developmental processes. Studies of related genes in other species, such as the cysteine proteinase SAG39 and fruit bromelain, link the family to similar proteolytic functions during senescence and stress responses.