HSP70 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.3HG0253530 (HSP70) on barley chromosome 3H encodes a heat shock cognate 70 kDa protein, a member of the Hsp70 family with ATPase and ATP-dependent protein folding chaperone activity. The gene is associated with protein folding in the endoplasmic reticulum, the ERAD pathway, and the unfolded protein response. It is linked to responses to heat, stress, viruses, and innate immunity, as well as to lipid metabolism and thirst response. The encoded protein localises to the ER chaperone complex, ER lumen, chloroplast membrane, tonoplast, cytoplasm, and nucleus. Studies of related genes in other species connect the family to similar stress and protein homeostasis functions.