COG1 — Glycine max

Summary

GmCOG1 (GLYMA_06G263900V4) encodes a protein with TIR, NB-ARC, and leucine-rich repeat domains characteristic of plant disease resistance proteins, and exhibits ATP hydrolase, ADP binding, NADP nucleosidase, and protein homodimerization activities. In soybean, this gene is associated with defense responses to oomycetes, bacteria, and fungi, as well as immune response, programmed cell death, and the hypersensitive response. It is also linked to lignin and phenylpropanoid biosynthesis, NAD breakdown, and virus-induced post-transcriptional gene silencing. The gene has been connected to downy mildew resistance, pathogen resistance, and disease resistance phenotypes. Studies of related genes in other species link the family to autoimmunity and hybrid incompatibility, while broader associations include seed size, days to flowering, root morphology, and molybdenum content.