COG1 — Glycine max

Summary

GmCOG1 (GLYMA_06G265000V4) on soybean chromosome 6 encodes a protein with TIR, NB-ARC, and leucine-rich repeat domains characteristic of plant disease resistance proteins, and exhibits ATP hydrolase, ADP binding, NADP nucleosidase, and DPNase activities. The gene is associated with immune responses, including defense against oomycetes, bacteria, and fungi, as well as antiviral response, virus-induced PTGS, and hypersensitive response-programmed cell death. It is linked to downy mildew resistance, pathogen resistance, and disease resistance phenotypes. Additional associations include lignin and phenylpropanoid biosynthesis, sporulation, NAD breakdown, and embryo shoot apical meristem specification. The protein localizes to the plasma membrane, cytoplasm, nucleus, Golgi membrane, and endoplasmic reticulum membrane. Studies of related genes in other species link the family to autoimmunity and traits including seed size, flowering time, root morphology, and molybdenum content.