M2 — Daucus carota subsp. sativus

Summary

DCAR_026129, also known as DcM2 and by multiple CYP and cyclophilin synonyms, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) on carrot chromosome 7. The product possesses cis-trans proline isomerase activity, cyclosporin A binding, salicylic acid binding, and additional annotated molecular functions including GTP:GDP antiporter activity, U5 and U2 snRNA binding, L-serine O-acetyltransferase activity, peroxidase activity, and histone and chromatin binding. DcM2 is associated with diverse biological processes such as protein proline isomerization, chaperone-mediated protein complex assembly, alternative mRNA splicing, response to light intensity, arsenic, and chlorate, as well as endosome transport and planar polarity establishment. The gene is linked to numerous agronomic traits including variegated leaf, starch grain synthesis, respiration and photosynthetic rates, sucrose content, root mass density, root hair length, herbicide and zinc sensitivity, temperature stress response, phototropism, and jasmonic acid content. It localizes to the Golgi, thylakoid lumen, secretory vesicle, and proteasome. Studies of related genes in other species connect the cyclophilin family to cold stress tolerance, drought response, hydrotropism, phototropism, embryo patterning, and resistance to Botrytis cinerea.