E2F1 — Daucus carota subsp. sativus

Summary

DCAR_020719 (DcE2F1) on carrot chromosome 6 encodes a protein with E2F and winged-helix DNA-binding domains, possessing DNA-binding, transcription factor, and protein heterodimerization activities. It is associated with cell cycle regulation, including G1/S transition, and modulation of cell proliferation, as well as trichome morphogenesis and programmed cell death. The gene is linked to responses to salicylate, jasmonic acid, ethylene, and auxin, and to DNA damage sensor activity. Associations with nitrate uptake, cell cycle traits, root distal stem cell maintenance, and virus resistance have been noted. The protein localizes to the nucleus and cytoplasm and is associated with the DP/Rb/MuvB complex. Studies of related genes in other species connect the E2F family to endoreduplication, leaf development, cell division, and drought tolerance.