M2 — Daucus carota subsp. sativus

Summary

DCAR_020736, symbol M2 (also known as DcM2, CYP22, and DcCYCLOPHILIN), encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) on carrot chromosome 6. The product belongs to the Cyclophilin_A-like family and possesses cis-trans proline isomerase activity and cyclosporin A binding capacity. This gene is associated with protein folding, regulation of protein refolding, and sensitization. It is linked to responses to abscisic acid, salt, and mannitol, as well as activation of the salinity response and carotenoid anabolism. The protein localizes to the chloroplast stroma, cytosol, plasma membrane, cytoplasm, and nucleus. Studies of related genes in other species link the family to PPIase activity (EC 5.2.1.8), though this is not established for DcM2 itself.