E2F1 — Daucus carota subsp. sativus

Summary

DCAR_006178, designated DcE2F1 on carrot chromosome 2, encodes a protein with E2F winged-helix DNA-binding and dimerisation domains, possessing DNA-binding, transcription cis-regulatory region binding, protein heterodimerisation and DNA damage sensor activities. The gene is associated with cell cycle regulation, including G1/S transition, DNA re-duplication, and both upregulation and downregulation of cell proliferation and transcription. It is linked to trichome morphogenesis, programmed cell death, and responses to auxin, jasmonic acid, ethylene and salicylate. Associations include nitrate uptake, cell cycle traits, DNA damage response, increased zeocin tolerance with reduced root growth inhibition, cell elongation, germline development, virus resistance, root distal stem cell maintenance and nitrate assimilation. The product localises to the nucleus, cytoplasm and DP/Rb/MuvB complex. Related genes in other species are linked to endoreduplication, S phase progression, leaf development, cell division, transcriptional activation and geminivirus infection susceptibility.