ADH — Daucus carota subsp. sativus

Summary

DCAR_006539 (symbol ADH, preferred name DcADH-P1) on carrot chromosome 2 encodes a protein with S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity and aldo-keto reductase (NAD) activity, and binds zinc. It belongs to the GroES-like superfamily. The gene is associated with fermentation, methanal catabolism, the glyoxylate cycle, gluconeogenesis, lignin anabolism, nitric oxide storage, cell growth, seed germination, and homologous recombination. In carrots, the ADH-P3 variant has been linked to the hypoxia response. The encoded product localises to the cytosol. Associations with lignin content have also been noted. Studies of related genes in other species connect the family to EC 1.1.1.1 activity, though this is not established for the carrot gene itself.