RDR1 — Cucumis sativus

Summary

CSA_5G239640, symbol RDR1 (also known as ATRDRP1, CsATRDRP1, CsRDR1) in cucumber (Cucumis sativus) on chromosome 5, encodes an RNA-dependent RNA polymerase (EC 2.7.7.48) with RdRP activity and RNA binding, belonging to the RDRP family with RRM_RDR1/2-like and PH_RDR1/2-like domains. This gene is associated with posttranscriptional gene silencing by RNA, siRNA processing, and positive regulation of posttranscriptional gene silencing. It is linked to antiviral defense, viral resistance, and resistance to Sclerotinia sclerotiorum and Fusarium brachygibbosum, as well as herbivore and drought resistance. Additional associations include cuticular wax biosynthesis, phenylpropanoid and secondary metabolite biosynthesis, response to salicylate and jasmonic acid signaling, hypersensitivity, phloem transport, and maintenance of shoot apical meristem identity. The product localizes to the nucleus and the RNA-dependent RNA polymerase complex. Related genes in other species link the RDR1 family to viral defense, salicylic acid response, and insect herbivore resistance.