ICDH — Cucumis sativus

Summary

CsICDH (CSA_5G346550) on cucumber chromosome 5 encodes a protein with isocitrate/isopropylmalate dehydrogenase domains and NADP-dependent isocitrate dehydrogenase activity (EC 1.1.1.42), annotated with NADP isocitric dehydrogenase, NAD isocitric dehydrogenase, NAD binding, and metal binding activities. The gene is associated with the TCA cycle, glyoxylate cycle, aerobic and anaerobic respiration, fermentation, nitrate and NAD(P) metabolism, regulation and downregulation of photosynthesis, response to hypoxia and zinc, and intracellular signal transduction. Its product localizes to chloroplast thylakoid and stroma, mitochondria, plastid, cytosol, apoplast, and plasmodesmata. CsICDH is linked to photosynthetic rate, chlorophyll content, respiration rate, sugar content, root morphology, salt tolerance, nitrogen metabolism, redox homeostasis, hydraulic conductivity, and histone methylation. Studies of related genes in other species connect the family to drought tolerance, salt response, oxidative stress, disease tolerance, seed weight, and starch content.