CAD1 — Cucumis melo

Summary

MELO3C016498.2 (CmCAD1) on melon chromosome 7 encodes a MACPF domain-containing protein of the CAD1/NSL1-like family. The gene is associated with defense responses, including callose deposition, immune response, programmed cell death, and hypersensitive response cell death. It is linked to regulation of salicylic acid metabolism and signaling, as well as lignin anabolism, water transport, dedifferentiation, and responses to sorbitol, salinity, and fungi. CmCAD1 has been connected to flower and root development. Associations with agronomic traits include lignin content, drought tolerance, and heavy metal tolerance (cadmium, zinc, arsenic). Phenotypic links involve cell death regulation, dwarfism with necrotic leaf lesions, altered disease resistance, immunity to Pseudomonas syringae, salicylic acid accumulation, and phyllosphere microbiota composition. The protein localizes to the extracellular region, plasma membrane, and nucleus. Studies of related genes in other species further link the family to pathogen resistance and immunity.