M2 — Cucumis melo

Summary

MELO3C012489.2, also known as CmM2, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) on melon chromosome 11. The product possesses cis-trans proline isomerase activity, cyclosporin A binding, and additional annotated molecular functions including salicylic acid binding, peroxidase activity, and histone binding. CmM2 is associated with diverse biological processes such as protein proline isomerization, regulation of ARF protein signal transduction, alternative mRNA splicing, basipetal auxin transport, and responses to light intensity, sulfate starvation, and arsenic. It has been linked to numerous agronomically relevant traits including variegated leaf, starch grain synthesis, sucrose content, photosynthetic rate, respiration rate, temperature stress response, herbicide sensitivity, root hair length, and jasmonic acid content. Localization evidence connects the protein to the Golgi stack, thylakoid lumen, secretory vesicle, and proteasome. Studies of related genes in other species link the cyclophilin family to drought response, cold stress tolerance, hydrotropism, phototropism, embryo patterning, and resistance to Botrytis cinerea.