CYP81E4 — Cicer arietinum

Summary

CYP81E4, also known as PsCYP81E4, is a cytochrome P450 monooxygenase on chickpea chromosome 7LG7. The encoded enzyme exhibits piperitol synthase activity, 4'-methoxyisoflavone 2'-hydroxylase activity, isoflavone 2'-hydroxylase activity, and isoflavone 3'-hydroxylase activity, and has oxidoreductase activity that incorporates molecular oxygen with NAD(P)H as a donor. It binds heme and iron and localizes to the ER membrane. This gene is associated with secondary metabolism, calcium signaling, response to heat, and signal transduction. Related genes in other species link the family to isoflavone hydroxylation and piperitol synthesis, though these specific activities are not yet established in chickpea.