PPAR — Capsicum annuum

Summary

The pepper (Capsicum annuum) gene T459_03796 (PPAR) on chromosome 1 encodes a glyoxylate/hydroxypyruvate reductase HPR3, a D-isomer-specific 2-hydroxyacid dehydrogenase with NAD(P)-binding domains. The enzyme exhibits multiple oxidoreductase activities, including glyoxylate reductase (NADH), hydroxypyruvate reductase (NADPH), glycerate dehydrogenase (NAD+), formate dehydrogenase (NAD+), and D-lactate dehydrogenase (NAD+) activities. PPAR is associated with photorespiration, the oxidative photosynthetic carbon pathway, formate breakdown, and fatty acid metabolism. The protein localises to mitochondria and the cytosol. The gene has also been linked to carotenoid content. Studies of related genes in other species connect the family to formate dehydrogenase (FDH), glycerate dehydrogenase (GDH), and hydroxyphenylpyruvate reductase (HPPR) activities, as well as EC numbers 1.1.1.28, 1.1.1.29, and 1.1.1.110.