PDE1 — Camelina sativa

Summary

CsPDE1 (CSA06G052020) on Camelina sativa chromosome 6 encodes a protein with D-isomer-specific 2-hydroxyacid dehydrogenase catalytic and NAD-binding domains, exhibiting multiple oxidoreductase activities including formate dehydrogenase (NAD+), hydroxypyruvate reductase [NAD(P)H], glyoxylate reductase (NADH and NADPH), glycerate dehydrogenase, and D-lactate dehydrogenase (NAD+). The gene is associated with photorespiration, the oxidative photosynthetic carbon pathway, formate breakdown, hypersensitivity, immune response, and homeostasis, and its product localizes to mitochondria and cytosol. CsPDE1 has been linked to phosphate-deficiency tolerance. Studies of related genes in other species connect the family to additional hydroxyphenylpyruvate reductase and glycerate dehydrogenase activities, though these associations are not yet established in Camelina sativa.