TRFL9 — Brassica oleracea var. botrytis
Summary
BoTRFL9 (TRFL9) on cauliflower chromosome 5 encodes a protein with Myb and SANT/Myb domains, a ubiquitin-like domain, and a TRP_plant domain, and is annotated with anthranilate phosphoribosyltransferase activity, DNA bending, and telomeric repeat binding. The gene is associated with telomere maintenance, including positive regulation via telomerase, and with cellular responses to UV-C, DNA damage, and chromosome localization. It is linked to stem cell population maintenance, root meristem growth, and meristem maintenance. Associations with traits include seed viability, flowering time, and disease tolerance. Phenotypic connections encompass tryptophan auxotrophy, stunted growth, reduced fertility, ovule abortion, and altered telomere length and stability. The protein localizes to the nucleus, chloroplast envelope, stroma, and plastid, as well as the telomeric region of chromosomes. Related genes in other species link the family to telomere function and telomere length regulation.
Annotations
- Chromosome
- 5
- Related genes
- TRFL9, TBP1, ATPOT1, TRP1, ETL1, AT4G33945, TERT
- GO terms
- DNA Binding, Bending, Telomerase Activity, DNA Damage Response, Anthranilate Phosphoribosyltransferase Activity, Plastid, Nucleus, Protein Homodimerization Activity, GO:0009507
- Publications
- 20226671, 26779251, 35560426, 19214203, 19783822, PMID:18431481, 12853623, 22623495
- Traits
- tryptophan biosynthesis, Progressive Telomere shortening with Progressive Telomere Shortening, Telomere Shortening Similar to Related Mutants, Telomere Shortening with Failure to Elongate Telomeres, Telomeres Maintain Length and Banding Profile in Double Mutant, Accelerated Telomere Loss, Early Growth Degeneration, Chromosomal Bridges, Decreased Root Meristem Size Correlating with Telomere Length Reduction, Anaphase Bridges and Chromosomal Defects in Late Generation Mutants