BRCA1 — Brassica oleracea var. botrytis

Summary

BoBRCA1, the cauliflower (Brassica oleracea var. botrytis) gene on chromosome 3, encodes a protein with ubiquitin-protein transferase activity, DNA binding, and protein binding, containing BRCA1-associated, RING, and BRCT domains. It is associated with cellular response to gamma radiation, macroautophagy, autophagy, homologous recombination (HDR), DNA recombination, regulation of meristem organisation, NO storage, homeostasis, and leaf development, and localises to the nucleus. The gene is linked to shoot apical meristem development, root mass density, quiescent centre maintenance, genome stability and integrity, DNA repair, homologous recombination, cadmium stress response, geminivirus resistance, mitomycin C sensitivity, and abnormal meristem development with inhibited root growth. Studies of related genes in other species link the family to DNA crosslink repair, shoot apical meristem organization, dehydration stress tolerance, and DNA double-strand break repair.