IRT1 — Brassica oleracea

Summary

BoIRT1 (BOLC102_C03P088330.1) on cabbage chromosome 3 encodes a ZIP family metal transporter with iron channel activity and copper, manganese, zinc and cadmium ion transmembrane transporter activities. It also exhibits phosphoinositide, ubiquitin, mRNA and protein binding. The gene is associated with metal homeostasis, including iron, zinc, cadmium and nickel transport, and with cellular iron ion homeostasis, manganese ion transport and cadmium transport. BoIRT1 is linked to photosynthetic rate and efficiency, chlorophyll content, chloroplast development, plant growth and development, root and lateral root development, leaf development, disease resistance, and responses to salt, chromium, uranium and hypoxia. It is also associated with auxin anabolism, downregulation of abscisic acid signalling, endosome membrane budding, MVB formation, and localises to the plasma membrane, endosome, late endosome membrane, TGN and ESCRT I complex. Studies of related genes in other species link the family to iron uptake, acquisition and translocation, nickel and arsenic accumulation, and cadmium sensitivity.