GR1 — Brassica oleracea

Summary

BoGR1, encoded by gene BOLC102_C03P056770.1 on cabbage chromosome 3, is a glutathione reductase (GSHR) family protein with glutathione reductase, thioredoxin reductase (NADPH), dihydrolipoyl dehydrogenase (NADH), and leghemoglobin reductase activities, and binds NADP and FAD. It is associated with the ascorbate-glutathione cycle, cellular respiration, ascorbate and glutathione metabolism, glycine decarboxylation, 2-oxoglutarate metabolism, cell redox homeostasis, and responses to oxidative stress, ethylene anabolism, NO storage, carbohydrate metabolism, and seed germination. The protein localizes to mitochondria, the mitochondrial lumen, the glycine cleavage system, the KGDHC complex, and the cytosol. BoGR1 is linked to protein and chlorophyll content, seed dormancy, pollen tube growth, salicylic acid accumulation, cadmium and ozone tolerance, sulfur assimilation, glutathione biosynthesis, hydrogen peroxide tolerance, lesion formation, and pathogenesis-related gene expression. Studies of related genes in other species connect the family to oxidative stress tolerance, cellular redox homeostasis, salinity, heat, cold, and aluminum tolerance, glutathione and cysteine accumulation, and cell cycle regulation.