HMA2 — Brassica napus

Summary

BnHMA2 (DARMORV10_C07P57510.1) on oilseed rape chromosome C07 encodes a P-type ATPase of the IB subfamily, a heavy metal-transporting ATPase with copper, zinc, cadmium and calcium transporter activities, copper binding and ATP hydrolase activity. The gene is associated with detoxification of copper ions, copper and zinc ion homeostasis, proton export across the plasma membrane, cell pH regulation, response to toxic substances, pollen germination and membrane transport. It localises to the vacuolar, Golgi and plasma membranes. Associations with photosynthetic rate, germination rate, stomatal resistance, zinc partitioning, cadmium tolerance and translocation, metal homeostasis, fungal resistance, and cadmium accumulation have been reported. Studies of related genes in other species link the family to zinc homeostasis, cadmium transport and xylem loading, and long-distance cadmium translocation.