ICDH — Brachypodium distachyon

Summary

BdICDH (BRADI_2G45420V3) on chromosome 2 of Brachypodium distachyon encodes an NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) with NAD and NADP isocitric dehydrogenase activity, copper and magnesium binding, and protein homodimerization activity. The gene is associated with the TCA cycle, glyoxylate cycle, isocitrate and NAD(P) metabolism, brassinosteroid-mediated signalling, defence response to bacteria, chemotaxis, biofilm formation, and response to zinc. Its product localizes to chloroplast thylakoid and stroma, mitochondria, plastid, cytosol, plasmalemma, apoplast, and plasmodesmata. Associations with photosynthetic rate, root morphology, leaf hydraulic conductivity, redox homeostasis, and histone methylation have been noted. Studies of related genes in other species link the family to drought and salinity tolerance, leaf relative water content, net photosynthetic rate, chlorophyll content, and pathogen resistance.