HRD1 — Beta vulgaris subsp. vulgaris

Summary

BVRB_3G067640, designated HRD1, encodes a RING-type domain-containing protein with ubiquitin ligase activity and ubiquitin binding capability, localizing to the ER membrane, endomembrane system, cytosol, and plasmalemma. It is associated with the ERAD pathway, protein ubiquitination, ubiquitin-dependent proteolysis, and the proteasomal pathway, as well as positive regulation of the hypersensitive response. The protein contains TPR_SYVN1_N, CUE, and zinc finger (RING, RING/FYVE/PHD) domains. Studies of related genes in other species link the family to EC 2.3.2.27 (RING-type E3 ubiquitin transferase) activity.