ERF4 — Arabidopsis thaliana

Summary

AT3G15210, designated ERF4 (also known as RAP2.5), encodes a protein containing an AP2/ERF DNA-binding domain and displaying transcription corepressor activity, transcription coactivator activity, DNA binding, protein homodimerization activity, and kinase binding. In Arabidopsis, ERF4 is associated with salt tolerance, root elongation, anthocyanin biosynthesis, hypertonic stress response, and transcriptional repression. It is linked to biological processes including cellular response to drought, downregulation of ethylene mediated signaling pathway, induced systemic resistance, jasmonic acid mediated signaling pathway, chlorophyll breakdown, and cuticle, wax, and glucosinolate anabolism. The protein localizes to the nucleus, nucleolus, cytosol, and mediator complex. ERF4 is also connected to strigolactone signaling, jasmonic acid signaling, brassinosteroid signaling, gravitropism, and regulation of seed size. Related genes in other species link the family to cold tolerance, TYLCV resistance, and stress tolerance.