PEN2 — Arabidopsis thaliana

Summary

AT2G44490, known as PEN2 or BGLU26 in Arabidopsis thaliana, encodes a beta-glucosidase with sinigrase activity (EC 3.2.1.21) and belongs to the glycosyl hydrolase family 1. This gene is associated with disease resistance, particularly pre-invasive nonhost resistance and penetration resistance to pathogens such as Phytophthora infestans and Colletotrichum species. It has been linked to resistance against Botrytis cinerea, Rhizoctonia solani, and Pythium irregulare, as well as powdery mildew resistance. PEN2 is associated with glucosinolate metabolism, including indole glucosinolate breakdown and biosynthesis, and with processes such as callose deposition, camalexin biosynthesis, and the metabolic burst. The protein localizes to the chloroplast envelope, membrane, and mitochondria. Studies of related genes in other species link the family to non-host resistance against Magnaporthe oryzae.