R1 — Zea mays

Summary

ZM00001EB375490 (R1, ZmR1) on maize chromosome 9 encodes a ribonucleoside-diphosphate reductase large subunit (RNRL1), an enzyme with ribonucleoside-diphosphate reductase activity (EC 1.17.4.1) that uses thioredoxin disulfide as an acceptor and binds ATP. This gene is associated with deoxyribonucleotide and deoxyribonucleoside triphosphate anabolism, DNA replication, and homeostasis. It is also linked to pigmentation, specifically anthocyanin and phenylpropanoid anabolism, and to anthocyanin content. The encoded protein localises to the cytoplasm and the RNR complex. Associations with leaf morphology, plant growth and development, plastid DNA degradation, photosynthesis, chloroplast function, and crinkled leaves with bleached edges and asymmetric growth have been observed. Related genes in other species link the family to DNA damage response and ribonucleotide reduction.