2A6 — Zea mays

Summary

ZM00001EB164860 (symbol 2A6, preferred name Bx6) on maize chromosome 4 encodes DIBOA-glucoside dioxygenase BX6, a 2-oxoglutarate-dependent dioxygenase with DIOX_N and IPNS-like Fe2OG oxygenase domains. The enzyme is annotated with DIBOA-glucoside oxygenase, 4-coumaroyl 2'-hydroxylase, and flavanone 3-dioxygenase activities. In maize, Bx6 is associated with aphid resistance and linked to defense responses including callose deposition, induced systemic resistance, and responses to insects. The gene is associated with jasmonic acid, ethylene, coumarin, terpenoid, and indole glucosinolate biosynthesis, as well as auxin transport and cellular detoxification. Associations extend to agronomic traits including drought tolerance, disease tolerance, photosynthetic rate, protein content, heterosis, and insect damage response. The protein localizes to the cytosol, cytoplasm, and nucleus. Studies of related genes in other species link the family to pathogen resistance, indolic glucosinolate biosynthesis, and callose deposition.