NBR1 — Triticum aestivum

Summary

TRAESCS6B02G236800 (symbol TaNBR1) on wheat chromosome 6B encodes a ZZ-type domain-containing protein with ubiquitin-binding, Atg8-specific protease, APG8 ligase and ubiquitin-protein transferase activities. It is associated with protein lipidation, polymerization, targeting to the vacuole during autophagy, and negative regulation of leaf senescence. The gene has been linked to responses to abscisic acid, cadmium, thermal stimulus, salinity, mannitol, thirst, and fungal defence. Localization evidence places the product at the phagophore, vacuolar lumen, cytoplasmic vesicle, vacuole, mitochondria, cytoplasm, and nucleus. Trait associations include grain number, seed yield, leaf yellowing tolerance, drought tolerance, wheat powdery mildew disease response, days to heading, germination rate, root development, and oxidative stress response. Studies of related genes in other species connect the family to selective autophagy, pexophagy, heat resistance, pathogen tolerance, seed yield, and abscisic acid signaling.