BAD1 — Sorghum bicolor

Summary

SORBI_3004G250900, designated BAD1 (also known as SbBAD1 and SbALDH2), encodes an aldehyde dehydrogenase domain-containing protein with betaine-aldehyde dehydrogenase (NAD+) activity (EC 1.2.1.36) and broad aldehyde dehydrogenase activity. This sorghum gene on chromosome 4 is associated with cellular detoxification of aldehydes, retinoic acid biosynthesis, green leaf volatile biosynthesis, and response to water and anoxia. It has been linked to leaf water potential and drought tolerance. The encoded protein localizes to mitochondria and cytosol and participates in proline degradation and amino acid catabolism pathways. Studies of related genes in other species connect the family to additional aldehyde dehydrogenase activities (EC 1.2.1.28, 1.2.1.39), though these associations are not yet established for sorghum.