ERD8 — Sorghum bicolor

Summary

SbERD8 (SORBI_3002G243200) on sorghum chromosome 2 encodes a member of the heat shock protein 90 (Hsp90) family, characterized by Hsp90 and HATPase domains, and annotated with ATP-dependent protein folding chaperone, transcription regulator, and ADP-ribosyl cyclase activities. The gene is associated with diverse biological processes including cellular responses to brassinosteroid and calcium ion stimuli, photoentrainment of the circadian clock, miRNA-mediated gene silencing, and negative regulation of cellulose biosynthesis. It has been linked to traits such as maturity time, photoperiod-sensitive flowering, plant reproduction, and responses to downy mildew, aphids, and viral disease. Additional associations include heat stress response, chilling-induced chlorosis, arsenite stress, and reactive oxygen intermediate accumulation. The protein localizes to the chloroplast outer membrane, ER lumen, proteasome, and perinuclear cytoplasm. Related genes in other species are associated with pathogen resistance, heat shock response, floral transition, and male fertility.