M2 — Solanum tuberosum

Summary

StM2 (PGSC0003DMG400025806) on potato chromosome 1 encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding and cis-trans proline isomerase activity, containing cyclophilin and tetratricopeptide repeat domains. The gene is associated with protein folding, regulation of protein refolding, and secretion, as well as wound healing, cell growth, and responses to abscisic acid, salt, and mannitol. It has been connected to phenylpropanoid, fatty acid, and lipid metabolism, virus-induced post-transcriptional gene silencing, and nitric oxide storage. The product localises to the chloroplast stroma, cytosol, cytoplasm, nucleus, and plasmalemma. StM2 is also linked to salt tolerance (SALTTL). Studies of related genes in other species further connect this family to protein folding and stress responses.