FDH1 — Solanum tuberosum

Summary

PGSC0003DMG400000496 (FDH1) on potato chromosome 2 encodes a protein with D-isomer-specific 2-hydroxyacid dehydrogenase and NAD(P)-binding domains, annotated with formate dehydrogenase, glyoxylate reductase, hydroxypyruvate reductase, and glycerate dehydrogenase activities (EC 1.17.1.9). The gene is associated with formate metabolism, the oxidative photosynthetic carbon pathway, and responses to water, salicylic acid, and fermentation. It has been linked to drought tolerance, photosynthetic rate, disease tolerance, and powdery mildew resistance, as well as abscisic acid and jasmonate signaling, seed germination, and seedling growth. Localization evidence connects FDH1 to plastids, mitochondria, thylakoids, and the cytosol. Studies of related genes in other species link the family to drought recovery, net photosynthetic rate, oxidative stress tolerance, and formaldehyde response.