GPX4 — Solanum lycopersicum

Summary

SlGPX4 (SOLYC12G056230.2) on tomato chromosome 12 encodes a glutathione peroxidase with phospholipid-hydroperoxide glutathione peroxidase activity, belonging to the thioredoxin-like superfamily and containing glutathione peroxidase active-site and conserved-site domains. The enzyme is associated with the ascorbate-glutathione cycle, response to glutathione, lycopene breakdown, protein oxidation, and reactive nitrogen species metabolism. It localises to the chloroplast stroma, cytosol, and nucleus. SlGPX4 is linked to numerous agronomic traits including fruit weight, lycopene, carotenoid, flavonoid, sugar, and soluble protein content, as well as leaf chlorophyll content, specific leaf area, leaf thickness, plant height, stem diameter, root weight, root length, seed dormancy, net photosynthetic rate, water use efficiency, stomatal resistance and opening, and responses to salt and photooxidative stress. Studies of related genes in other species connect the family to heat, salt, and oxidative stress tolerance.