ICS1 — Solanum lycopersicum

Summary

SOLYC06G071030.3, also known as ICS1, SID2, or EDS16, encodes a protein with isochorismate mutase activity and aminodeoxychorismate synthase activity, belonging to the IsoChor_synthase and MenF-like families. The enzyme localizes to the plastid and is associated with salicylic acid biosynthesis and signaling, as well as phylloquinone, folate, and tetrahydrofolate anabolism. This tomato gene on chromosome 6 is linked to numerous defense-related phenotypes, including disease resistance, nonhost resistance to Xanthomonas citri and rust fungi, powdery mildew resistance, and systemic acquired resistance. It is also connected to root development, lateral root number, leaf senescence, and stress tolerance traits such as drought, salt, and cadmium tolerance. Additionally, associations with fruit size, lycopene content, net photosynthetic rate, stomatal resistance, and seedling vigor have been reported. Studies of related genes in other species link the family to salicylic acid accumulation, basal defense, and heat and drought tolerance.