LIP1 — Pisum sativum

Summary

PSAT6G139920 (symbol LIP1, also known as PsLIP1) on garden pea chromosome 6LG2 encodes a lipoic acid synthase (EC 2.8.1.8), a mitochondrial enzyme that binds 4Fe-4S clusters and metal ions. The gene is associated with lipoate biosynthesis and protein lipoylation, as well as glycine breakdown. It has been linked to photomorphogenesis, skotomorphogenesis, and dark adaptation, and to responses to auxin, strigolactone, and stress. LIP1 is also associated with strigolactone biosynthesis and with the regulation of thirst responses. The product localises to the mitochondrial lumen. Studies of related genes in other species link the family to lipoic acid synthase activity and mitochondrial function.