ALS — Pisum sativum

Summary

PSAT1G205600 (symbol ALS) in garden pea (Pisum sativum) on chromosome 1LG6 encodes an acetolactate synthase, a thiamine pyrophosphate-dependent enzyme that also exhibits 2-hydroxyacyl-CoA lyase and pyruvate decarboxylase activities, binds TPP, FAD, and magnesium, and localises to the chloroplast stroma as part of the acetolactate synthase complex. The gene is associated with branched-chain amino acid biosynthesis, valine biosynthesis, ethanol fermentation, fatty acid alpha-oxidation, the shikimate pathway, aerobic respiration, and response to herbicide. It has been linked to herbicide tolerance, particularly through the G121A variant, and to amino acid content. Studies of related genes in other species connect the ALS family to herbicide resistance (including sulfonylurea and imidazolinone resistance), seed weight, plant height, nitrogen content, salt response, and overall plant growth and development.