HSP70 — Pisum sativum

Summary

PSAT1G100800 (HSP70) on garden pea chromosome 1LG6 encodes a protein with heat shock protein 70 family and ATPase domains, annotated with ATP hydrolase activity, ATP binding, ubiquitin ligase activity, protein folding chaperone function, and protein phosphatase activator and regulator activities. The gene is associated with diverse biological processes including cytoplasm protein quality control, ubiquitin-dependent protein breakdown via the N-end rule pathway, mitochondrial protein import and biogenesis, S-nitrosylation, meiotic sister chromatid cohesion, auxin polar transport, seed maturation, and the ERAD pathway. Its product localises to the ER chaperone complex, ER lumen, chloroplast membrane, cytosol, nucleus, and PP2A complex. Related genes in other species include BiP, linking the family to endoplasmic reticulum stress responses.