PPAR — Pisum sativum

Summary

PSAT0SS4236G0160, designated PPAR, on garden pea (Pisum sativum) chromosome CAADHX020023867.1, encodes a protein containing a D-isomer 2-hydroxyacid dehydrogenase catalytic domain. The product exhibits glyoxylate reductase (NADH and NADPH), hydroxypyruvate reductase (NADPH and NAD(P)H), and D-lactate dehydrogenase (NAD+) activities, and binds NAD. It is associated with photorespiration, lipid metabolism including fatty acid oxidation, lipogenesis, and lipolysis, as well as glucose homeostasis, glucose metabolism, and broader homeostatic processes. The protein is linked to fat cell differentiation, digestion, and the viral life cycle, and localises to the cytosol. Studies of related genes in other species connect the family to EC numbers 1.1.1.110, 1.1.1.26, 1.1.1.28, and 1.1.1.79, and to the proteins 2KGR and PPAR.