CDC2 — Pisum sativum

Summary

PSAT0S3481G0080 (CDC2) in garden pea (Pisum sativum) encodes a dual-specificity protein kinase (EC 2.7.12.1) with cyclin-binding and RNA polymerase II CTD heptapeptide repeat kinase activity, belonging to the CLK kinase family. This gene is associated with cell cycle control, including G1/S and G2/M transitions, mitosis, meiotic cell cycle modulation, and regulation of mitotic entry. It is also linked to response to UV-C, intracellular signal transduction, regulation of growth and gene expression, translation elongation, protein synthesis, and rRNA processing. The encoded protein localizes to the nucleus, cytoplasm, spindle, CDK holoenzyme, and NRD complex. Studies of related genes in other species link the family to additional kinase activities (EC 2.7.11.22–24), though these associations are not established for pea CDC2 itself.