DMT1 — Phaseolus vulgaris

Summary

PHAVU_002G014300, designated DMT1 (also known as PvNRAMP3 and PvNRAMP4), encodes a member of the NRAMP family of metal ion transporters on chromosome 2 of French bean (Phaseolus vulgaris). The product possesses metal ion transmembrane transporter activity, specifically for manganese ions. DMT1 is associated with the transport of lead, manganese, and iron ions, as well as the regulation of vacuolar transport and cellular homeostasis of manganese and iron. It has been linked to responses to iron, zinc, bacteria, and nematodes, and to the positive regulation of reactive oxygen species metabolism. The protein localises to the tonoplast, vacuolar membrane, trans-Golgi network membrane, and plasmodesmata. Associations with copper homeostasis, iron remobilisation, iron localisation in seeds, seed germination, and growth under manganese deficiency have been noted. Studies of related genes in other species link the family to photosystem II function, iron deficiency responses, manganese and zinc accumulation, and pathogen resistance.