PMIT1 — Oryza sativa Japonica

Summary

OS06G0676000 (PMIT1/NRAMP3) encodes a member of the NRAMP family of metal ion transporters, with molecular functions including manganese, iron, cadmium, and aluminium ion transmembrane transporter activity. The gene is associated with manganese ion homeostasis and transport, cellular responses to manganese and cadmium, aluminium transport, phloem loading, and positive regulation of reactive oxygen species metabolism. In rice, family members NRAMP1, NRAMP5, and NRAMP6 have been linked to broad-spectrum disease resistance, immunity, cadmium accumulation and tolerance in shoots and grain, manganese accumulation, grain yield and quality, root and xylem development, and cobalt accumulation and toxicity tolerance. The encoded protein localises to endosome, vacuolar, Golgi, and plasma membranes, as well as plasmodesmata and plastids. Related genes in other species are associated with iron mobilisation, cadmium sensitivity, and pathogen resistance.