PMIT1 — Oryza sativa Indica Group

Summary

BGIOSGA025476 (symbol PMIT1, also known as NRAMP1, NRAMP5, and other NRAMP family members) on chromosome 7 of Indica rice encodes a member of the NRAMP family of metal ion transporters, with molecular functions including metal ion, manganese, iron, aluminium, and cadmium transmembrane transporter activity. The gene is associated with multiple metal-related processes such as manganese, iron, aluminium, cadmium, and lead ion transport and homeostasis, as well as positive regulation of reactive oxygen species metabolism and cellular responses to metal ions. In rice, PMIT1 family members have been linked to cobalt accumulation and toxicity tolerance, iron uptake, cadmium accumulation in shoots and grain, manganese accumulation, disease resistance, root and lateral root development, grain quality, and yield. The encoded protein localises to endosome, vacuolar, Golgi, and plasma membranes, as well as plasmodesmata and plastids.