HMA2 — Oryza sativa Indica Group

Summary

BGIOSGA024568 (HMA2, also known as OsHMA3) on chromosome 7 of Indica rice encodes a P-type ATPase of the IB subfamily with cation-transporting ATPase activity, including cadmium, zinc, and copper transporter activities. The protein localises to the vacuolar membrane, Golgi, and plasmodesmata. In rice, HMA3 is associated with cadmium transport from roots to shoots, root elongation, and drought stress response. It is also linked to zinc homeostasis, metal detoxification, and tolerance to cadmium and lead. The gene is associated with reproductive period, grain yield, bacterial disease response, and nitrate uptake. Studies of related genes in other species link the family to zinc translocation, cadmium xylem loading, and seed zinc content, as well as cadmium sequestration in roots.