IRT1 — Medicago truncatula

Summary

MTR_4G083570 (MtIRT1) on barrel medic chromosome 4 encodes a ZIP family metal transporter with copper, zinc, iron, manganese and cadmium ion transmembrane transporter activity, as well as ubiquitin and phosphoinositide binding. MtIRT1 is associated with nitrogen fixation, nodulation, seedling development, cellular response to hypoxia, and regulation of abscisic acid signaling. It localises to the plasma membrane, endosome, late endosome membrane, TGN and nucleus. The gene is linked to photosynthetic rate, plant growth and development, salt tolerance, iron homeostasis, cadmium detoxification and accumulation, zinc accumulation, root and leaf development, chloroplast development, disease resistance, and circadian period length. Related genes in other species are associated with iron acquisition and transport, zinc uptake and tolerance, nickel and copper accumulation, cadmium sensitivity, and vacuolar biogenesis.