MTR_2G104140 — Medicago truncatula

Summary

MTR_2G104140 (MtTPL) encodes a TOPLESS family transcriptional corepressor containing LisH, CTLH and WD40 repeat domains, with annotated molecular functions including transcription corepressor activity, DNA-binding transcription repressor activity, and histone H3K4 demethylase activity. In barrel medic, MtTPL is associated with compound leaf morphogenesis, simple leaf morphogenesis, regulation of developmental vegetative growth, negative regulation of seed maturation, fruit abscission, anther dehiscence, and cellular responses to salt and zinc. The gene is linked to numerous agronomic traits including seed quality, fruit quality, stigma length, floral organ length, leaf area, trichome density, petal color, inflorescence size, and responses to nematodes, water stress, boron and potassium. MtTPL localises to chromatin-associated complexes including PRC2, SWI-SNF, Sin3-type and HDAC complexes. Studies of related genes in other species connect the TOPLESS family to embryonic patterning, meristem development, drought response, pathogen resistance, and anthocyanin and proanthocyanidin accumulation.