FAS5 — Daucus carota subsp. sativus

Summary

DCAR_008813 (symbol FAS5, also known as DcTOP1BETA or DcMGO1) on carrot chromosome 3 encodes a type I topoisomerase (EC 5.6.2.1) with DNA topoisomerase IB domains and DNA-binding, chromatin-binding, histone-binding, and protein-binding activities. The gene is associated with DNA topological change, replication, chromosome division, chromatin modelling, apoptotic process, autophagy, ascorbate metabolism, response to UV, shoot and flower morphogenesis, somatic embryogenesis, plant organ formation, stem cell population maintenance, and regulation of meristem size. It localises to the nucleus, nucleolus, chromosome, cytoplasm, cytosol, mitochondria, Golgi complex, and plant-type vacuole. Associations with agronomic traits include nitrate uptake, leaf composition, seedling growth, flowering time, salt tolerance, and abiotic stress response. Phenotypic connections include stem fasciation, phyllotaxis, organ primordium initiation, DNA endoreduplication, plant architecture, pathogen defence, salicylic acid signalling, and innate immunity. Studies of related genes in other species link the family to inflorescence fasciation, meristem size, leaf morphology, and stress tolerance.