M2 — Daucus carota subsp. sativus

Summary

DCAR_003158, the DcM2 gene on carrot chromosome 1, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with cyclosporin A binding and cis-trans proline isomerase activity. This gene is associated with protein folding, regulation of protein refolding, and sensitization. It is associated with responses to abscisic acid, salt, and mannitol, as well as activation of the salinity response. DcM2 is also linked to carotenoid anabolism. The encoded protein localizes to the chloroplast stroma, cytosol, cytoplasm, nucleus, and plasmalemma. Studies of related genes in other species link this family to peptidyl-prolyl isomerase activity (EC 5.2.1.8), though these specific functions are not yet established in carrot.